Glycosylation Protects Proteins against Free Radicals Generated from Toxic Xenobiotics
نویسندگان
چکیده
منابع مشابه
Glycosylation protects proteins against free radicals generated from toxic xenobiotics.
Free radicals generated during peroxidase-catalyzed oxidation of two xenobiotics, carcinogenic Sudan I and an anticancer agent ellipticine, easily attack unmodified proteins but not glycoproteins. A significant inverse correlation between the extent of glycosylation of proteins and the degree of binding of Sudan I or ellipticine radicals to these proteins was observed, whereby the protection on...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2010
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfq206